Human CellExp™ Soluble NRP-1, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Natural soluble neuropilin-1, soluble neuropilin-1, SNRP1, Neuropilin-1， Vascular endothelial cell growth factor 165 receptor， CD304，NRP, VEGF165R, UniProt O14786-2, isoform 2 Human CellExp™ Soluble neuropilin-1, Human Recombinant

Alternates names: N/A

Taglines: A membrane-bound receptor for both vascular endothelial growth factor and semaphorin family members.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: N/A

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: UniProt O14786-2

Recombinant: True

Source: HEK 293 cells (Phe 22 - Lys 644)

Purity by SDS-PAGE #: ≥ 95% by SDS-PAGE gel

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: Expected weight of 71 kDa (6x His tag at the C-terminus)

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

Background Information: Neuropilin-1 isoform 2 (identifier: O14786-2) is also known as soluble NRP1 or SNRP1. The sequence of this isoform differs from the canonical sequence by 3 amino acids (aa 642-644, EFP → GIK). NRP1 is a membrane-bound receptor for both vascular endothelial growth factor and semaphorin family members. NRP1 has been implicated in vascularization and progression of cancers. A positive correlation has been shown between elevated NRP1 expression and tumor samples of the brain, prostate, breast, colon and lung. Soluble NRP1 is expressed differently than the intact NRP1 and is also a VEGF165 antagonist. Recently studies have shown that NRP1 binds to the S1 domain of SARS-CoV-2 spike protein via its b1 domain (aa 273-427). This may facilitate the entry of SARS-CoV-2 virus into the cells thereby making it a potential target for future antiviral drugs.

Amino acid sequence: Phe 22 - Lys 644

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans