Human CellExp™ TRAIL R2 / TNFRSF10B, Mouse recombinant

Biomolecule/Target: N/A

Synonyms: TNFRSF10B, TRAILR2, TRAIL-R2, CD262,DR5, KILLER, TRICK2, ZTNFR9, TRICKB

Alternates names: TNFRSF10B, TRAILR2, TRAIL-R2, CD262,DR5, KILLER, TRICK2, ZTNFR9, TRICKB

Taglines: Promotes the activation of NF-kappa-B

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 21933

NCBI Gene Symbol: Tnfrsf10b

Gene Source: Mouse

Accession #: Q9QZM4-1

Recombinant: True

Source: HEK 293 Cells

Purity by SDS-PAGE #: >90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.1 kDa. The protein migrates as 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.

Amino acid sequence: AA Asn 53 - Lys 180

Handling: Centrifuge the vial prior to opening.

Usage: N/A