Human CellExp™ TrkA, human recombinant

Biomolecule/Target: trkA

Synonyms: Trk-A, NTRK1, MTC, TRK, TRKA, Tyrosine kinase Receptor A

Alternates names: Trk-A, NTRK1, MTC, TRK, TRKA, Tyrosine kinase Receptor A

Taglines: NAD-binding component of TrK potassium transporter

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 947788

NCBI Gene Symbol: trkA

Gene Source: Human

Accession #: P39448

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 0.2 EU/μg

Activity (Specifications/test method): Neutralization assay

Biological activity: ED50 <1 μg/ml, measured in a neutralization assay in the presence of 10 ng/ml human β-NGF using TF-1 Cells.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 65~85 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized after extensive dialysis against PBS.

Reconstitution Instructions: Reconstituted in ddH2O or PBS at 100 μg/ml.

Background Information: Tyrosine kinase receptor A (Trk-A) is a member of the neurotrophic tyrosine kinase receptor family which includes three members: Trk-A, Trk-B and Trk-C. Trk-A is involved in the development and maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic neurons.

Amino acid sequence: APCPDACCPH GSSGLRCTRD GALDSLHHLP GAENLTELYI ENQQHLQHLE LRDLRGLGEL RNLTIVKSGL RFVAPDAFHF TPRLSRLNLS FNALESLSWK TVQGLSLQEL VLSGNPLHCS CALRWLQRWE EEGLGGVPEQ KLQCHGQGPL AHMPNASCGV PTLKVQVPNA SVDVGDDVLL RCQVEGRGLE QAGWILTELE QSATVMKSGG LPSLGLTLAN VTSDLNRKNV TCWAENDVGR AEVSVQVNVS FPASVQLHTA VEMHHWCIPF SVDGQPAPSL RWLFNGSVLN ETSFIFTEFL EPAANETVRH GCLRLNQPTH VNNGNYTLLA ANPFGQASAS IMAAFMDNPF EFNPEDPIPV SFSPVDTNST SGDP

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans