Human CellExp™ ACVR2B (Active), Human Recombinant

Biomolecule/Target: N/A

Synonyms: Activin A Receptor Type 2B; ACTR-IIB; ACTRIIB; HTX4

Alternates names: Activin A Receptor Type 2B; ACTR-IIB; ACTRIIB; HTX4

Taglines: Constitutively active receptor serine/threonine kinase that regulates many physiological processes

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 93

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: Q13705

Recombinant: True

Source: Human Cells

Purity by SDS-PAGE #: > 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per µg as determined by the LAL method

Activity (Specifications/test method): Immobilized Activin A at 5 μg/ml (100 μl/well) can bind Human ACVR2B. The ED50 of Human ACVR2B is 20.58 ng/ml

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 41.3 kDa calculated; 60 kDa observed

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized powder

Reconstitution Instructions: N/A

Background Information: Activin A receptor type 2B (ACVR2B) is a constitutively active transmembrane serine/threonine kinase that forms a complex with type I activin receptors to transduce activin signaling. Activin signaling is responsible for regulating many physiological and pathological processes including neuronal differentiation and survival, hair follicle development, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis.

Amino acid sequence: Ser 19 to Thr 134 with C-terminal Fc & 6xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans