Human CellExp™ BAFFR / TNFRSF13C, Fc Tag Human Recombinant

Biomolecule/Target: TNFRSF13C

Synonyms: BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin

Alternates names: BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin

Taglines: Promotes the survival of mature B-cells and the B-cell response

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 115650

NCBI Gene Symbol: TNFRSF13C

Gene Source: Human

Accession #: Q96RJ3

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human BAFF, His Tag at 5 μg/mL (100 μL/well) can bind Human BAFFR, Fc Tag with a linear range of 2-31 ng/mL

Results: N/A

Binding Capacity: Immobilized Human BAFF, His Tag at 5 μg/mL (100 μL/well) can bind Human BAFFR, Fc Tag with a linear range of 2-31 ng/mL

Unit Definition: N/A

Molecular Weight: 33.2 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration up to 0.2 mg/ml.

Background Information: BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans