Human CellExp™ CD58 / LFA-3, Fc Tag, human recombinant

Biomolecule/Target: CD58

Synonyms: CD58, LFA3, Ag3

Alternates names: CD58, LFA3, Ag3

Taglines: Ligand of T-lymphocyte CD2 glycoprotein

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 965

NCBI Gene Symbol: CD58

Gene Source: Human

Accession #: P19256

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human CD2, His Tag at 2 μg/mL (100 μL/well) can bind Human CD58, Fc Tag with a linear range of 10-156 ng/mL

Results: N/A

Binding Capacity: Immobilized Human CD2, His Tag at 2 μg/mL (100 μL/well) can bind Human CD58, Fc Tag with a linear range of 10-156 ng/mL

Unit Definition: N/A

Molecular Weight: 48.1 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans