Human CellExp™ EphA7 / EHK3 (Active), Human Recombinant

Biomolecule/Target: N/A

Synonyms: EPH Receptor A7; HEK11; Ephrin Type-A Receptor 7; EHK-3; EK11

Alternates names: EPH Receptor A7; HEK11; Ephrin Type-A Receptor 7; EHK-3; EK11

Taglines: Implicated in mediating nervous system development

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2045

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: Q15375

Recombinant: True

Source: Human Cells

Purity by SDS-PAGE #: > 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per µg as determined by the LAL method

Activity (Specifications/test method): Immobilized Human EphA7-His at 2 μg/ml (100 μl/well) can bind Human EFNA4-Fc-6His. The ED50 of Human EphA7-His is 1.5190 μg/ml

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 60.19 kDa predicted, 72 kDa observed

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized powder

Reconstitution Instructions: N/A

Background Information: The Ephrin Type-A Receptor 7 is a member of the ephrin receptor subfamily of protein-tyrosine kinases, which are implicated in mediating nervous system development. EphA7 binds to membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-depending bidirectional signaling between the neighboring cells. Interaction between EphA7 and its ligand EFNA5 regulates brain development through the modulation of cell-cell adhesion and repulsion. EphA7 has a repellent activity on axons, and may also regulate brain development through a Caspase-3-dependent proapoptotic mechanism. Overexpression of EphA7 is associated with multiple forms of carcinoma.

Amino acid sequence: Gln 28 to Ile 556 with C-terminal 6xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans