Biovision
Human CellExp™ Gremlin / GREM1, Human recombinant
- SKU:
- 26-P1124
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: Grem1
Synonyms: GREM1, CKTSF1B1, DAND2, DRM, PIG2
Alternates names: GREM1, CKTSF1B1, DAND2, DRM, PIG2
Taglines: A TGF-β antagonist
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 23892
NCBI Gene Symbol: Grem1
Gene Source: Human
Accession #: O70326
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGE #: > 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/μg
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.
Biological activity: Immobilized Human BMP-2, at 2 μg/mL (100 μL/well) can bind Human Gremlin, His Tag with a linear range of 0.8-81.9 ng/mL.
Results: N/A
Binding Capacity: Immobilized Human BMP-2, at 2 μg/mL (100 μL/well) can bind Human Gremlin, His Tag with a linear range of 0.8-81.9 ng/mL.
Unit Definition: N/A
Molecular Weight: 20.2 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Background Information: Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans