Human CellExp™ HDAC6, Human Recombinant, Active

Biomolecule/Target: HDAC6

Synonyms: HDAC6, HDAC6 protein, recombinant HDAC6, human HDAC6, HDAC, recombinant HDAC, recombinant human HDAC6, r_hu HDAC6, HDAC-6, HDAC-6 protein, recombinant HDAC-6, human HDAC-6, recombinant human HDAC-6, recombinant HDAC-6 protein, human HDAC-6 protein, recombinant human HDAC-6 protein, rh HDAC-6, rh HDAC-6 protein, KIAA0901, JM21, HD6, 10013, Q9UBN7, human cell expressed HDAC6, , human cell expressed HDAC-6, 293HEK

Alternates names: KIAA0901, JM21, HD6

Taglines: Regulates the acetylation status of non-histone substrates

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 10013

NCBI Gene Symbol: HDAC6

Gene Source: Human

Accession #: Q9UBN7

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥90%

Assay: SEC

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Deacetylation activity was determined using GAK(Ac)-AMC, Boc-K(Ac)-AMC and Fluor-de-Lys (RHK-K(Ac)-AMC) substrates.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 131 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.4

Reconstitution Instructions: N/A

Background Information: HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.

Amino acid sequence: N/A

Handling: Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.

Usage: For Research Use Only! Not to be used in humans