Human CellExp™ IL-13, Human Recombinant
- Usually Shipped in 5 Working Days
- 10 μg
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: IL13, ALRH, BHR1, MGC116786, MGC116788, MGC116789, P600, Interleukin-13
Alternates names: IL13, ALRH, BHR1, MGC116786, MGC116788, MGC116789, P600, Interleukin-13
Taglines: A mediator of allergic inflammation and disease
Country of Animal Origin: USA
NCBI Gene ID #.: 3596
NCBI Gene Symbol: IL13
Gene Source: Human
Accession #: P35225
Source: HEK293 cells
Purity by SDS-PAGE #: > 92%
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/μg
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.
Biological activity: Immobilized Human IL-13, Tag Free at 10 μg/mL (100 μL/well) can bind Anti-IL13 MAb, Human IgG4 with a linear range of 0.5-8 ng/mL.
Binding Capacity: Immobilized Human IL-13, Tag Free at 10 μg/mL (100 μL/well) can bind Anti-IL13 MAb, Human IgG4 with a linear range of 0.5-8 ng/mL.
Unit Definition: N/A
Molecular Weight: 13.4 kDa
Physical form description: Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Background Information: Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans