Human CellExp™IL-2, Human Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.
Alternates names: T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.
Taglines: A regulator of lymphocyte activities
Country of Animal Origin: USA
NCBI Gene ID #.: 3558
NCBI Gene Symbol: IL2
Gene Source: Human
Accession #: P60568
Source: HEK 293 cells
Purity by SDS-PAGE #: > 95% by SDS - PAGE
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): ED50 is typically 0.2 to 2 ng/mL. The specific activity was determined by the dose dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line) using BioVision’s Quick Cell Proliferation colorimetric Assay Kit Plus (Cat. No. K302).
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 16 kDa with a 6×His tag at the C-terminus
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Background Information: Interleukin-2 (IL-2) is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. IL-2 is one of the key cytokines for the immune system, tolerance and immunity. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma in cancer immunotherapy with long term disease control. In addition to being used as monotherapy, IL-2 can also be combined with other anticancer immunotherapies, such as adoptive cell transfer, vaccination, and blockade of immune checkpoint inhibitory molecules, such as cytotoxic T lymphocyte-associated antigen 4 and programmed death 1 monoclonal-antibodies as a promising treatment for metastatic cancer.
Amino acid sequence: Ala 21 – Thr 153
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans