Human CellExp™IL-2, Human Recombinant

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SKU:
26-P1385
Availability:
Usually Shipped in 5 Working Days
Storage Temperature:
-20°C
Shipping Conditions:
Gel Pack
Shelf Life:
12 months
zł1,213.70 - zł3,755.60
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Description

Biomolecule/Target: N/A

Synonyms: T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.

Alternates names: T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.

Taglines: A regulator of lymphocyte activities

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3558

NCBI Gene Symbol: IL2

Gene Source: Human

Accession #: P60568

Recombinant: FALSE

Source: HEK 293 cells

Purity by SDS-PAGE #: > 95% by SDS - PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): ED50 is typically 0.2 to 2 ng/mL. The specific activity was determined by the dose dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line) using BioVision’s Quick Cell Proliferation colorimetric Assay Kit Plus (Cat. No. K302).

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 16 kDa with a 6×His tag at the C-terminus

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

Background Information: Interleukin-2 (IL-2) is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. IL-2 is one of the key cytokines for the immune system, tolerance and immunity. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma in cancer immunotherapy with long term disease control. In addition to being used as monotherapy, IL-2 can also be combined with other anticancer immunotherapies, such as adoptive cell transfer, vaccination, and blockade of immune checkpoint inhibitory molecules, such as cytotoxic T lymphocyte-associated antigen 4 and programmed death 1 monoclonal-antibodies as a promising treatment for metastatic cancer.

Amino acid sequence: Ala 21 – Thr 153

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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