Human CellExp™ IL-5, Human Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: Interleukin-5, IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF
Alternates names: Interleukin-5, IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF
Taglines: Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Country of Animal Origin: USA
NCBI Gene ID #.: 3567
NCBI Gene Symbol: IL5
Gene Source: Human
Accession #: P05113
Source: HEK 293 cells
Purity by SDS-PAGE #: >95%
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): ED50 is typically < 1 ng/mL. The specific activity was determined by the dose dependent stimulation of the proliferation of Human TF-1 cells using BioVision’s Quick Cell Proliferation colorimetric Assay Kit Plus (Cat. No. K302).
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 14 kDa with a 6×His tag at the N-terminus
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Background Information: Interleukin-5 (IL-5) is identified by its ability to support the growth and terminal differentiation of mouse B cells to immunoglobulin secreting cells. IL-5 also exerts pleiotropic activities on various target cells including eosinophils and basophils via receptors of IL-5-specific α and common β-subunit. IL-5’s stimulation of eosinophil has been implicated in the pathogenesis of allergic inflammatory diseases, such as asthma. Targeting the interleukin-5 pathway offers benefit to patients with severe asthma. Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that has been approved as an add-on biological treatment for severe eosinophilic asthma, by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA).
Amino acid sequence: Ile 20 – Ser 134
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans