Biovision
Human CellExp™ Insulin R / CD220, Human Recombinant
- SKU:
- 26-P1377
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: Insulin R / CD220
Synonyms: INSR, Insulin receptor, IR, CD220
Alternates names: INSR, Insulin receptor, IR, CD220
Taglines: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 3667
NCBI Gene Symbol: IRS1
Gene Source: Human
Accession #: P06213-2
Recombinant: TRUE
Source: HEK 293 cells
Purity by SDS-PAGE #: >90% as determined by SDS-PAGE
Assay: N/A
Purity: N/A
Assay #2: N/A
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method): Immobilized Human Insulin R (28-944), His Tag at 5 μg/mL (100 μL/well) can bind Human IGF-II, Fc Tag with a linear range of 0.078-1.25 μg/mL
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 106.5 kDa (His 28 - Lys 944)
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. It is recommended to store at -20°C.
Background Information: Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.
Amino acid sequence: AA His 28 - Lys 944
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans