Human CellExp™ NKG2D / CD314, Fc Tag, Human Recombinant

Biomolecule/Target: N/A

Synonyms: NKG2D, CD314, KLRK1, NK cell receptor D

Alternates names: NKG2D, CD314, KLRK1, NK cell receptor D

Taglines: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 22914

NCBI Gene Symbol: KLRK1

Gene Source: Human

Accession #: P26718-1

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): Immobilized Human MICA, His Tag at 5 μg/mL (100 μL/well) can bind Human NKG2D, Fc Tag with a linear range of 4-63 ng/mL

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 43.1 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.

Amino acid sequence: Ile 73 - Val 216

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans