Human CellExp™ PD-L2 / B7-DC, mouse recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Alternates names: PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Taglines: A protein involved in the costimulatory signal essential for T-cell proliferation.
Country of Animal Origin: USA
NCBI Gene ID #.: 58205
NCBI Gene Symbol: Pdcd1lg2
Gene Source: Mouse
Accession #: Q9WUL5
Source: HEK 293 cells
Purity by SDS-PAGE #: ≥95%
Assay #2: N/A
Endotoxin Level: < 0.1 EU/μg
Activity (Specifications/test method): N/A
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 49.6 kDa
Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Background Information: Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans