Human CellExp™ Progranulin, Human Recombinant

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£291.54 - £2,210.20
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Biomolecule/Target: N/A

Synonyms: Acrogranin, Paragranulin, Granulin-1

Alternates names: Acrogranin, Paragranulin, Granulin-1

Taglines: Regulator of cell growth, wound healing, and tumorigenesis

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2896

NCBI Gene Symbol: GRN

Gene Source: Human

Accession #: P28799

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥90%


Purity: ≥90%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Measured by chemotaxis using THP-1 cells.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 88.0 kDa

Concentration: 0.5 mg/ml

Appearance: Liquid

Physical form description: Sterile filtered clear solution in PBS

Reconstitution Instructions: N/A

Background Information: Progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6.0 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 amino acids and having a molecular mass of 88.0 kDa. The Progranulin is purified by standard chromatographic techniques.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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