Human CellExp™Tie2Protein, Human Recombinant

Biomolecule/Target: N/A

Synonyms: VMCM,TEK,Recombinant Human Tie2,hTIE2,p140 TEK,VMCM1,TIE-2,CD202b,Tie2

Alternates names: VMCM,TEK,Recombinant Human Tie2,hTIE2,p140 TEK,VMCM1,TIE-2,CD202b,Tie2

Taglines: Human protein with His tag

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 7010

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: NP_000450.2; Q02763

Recombinant: TRUE

Source: HEK 293 Cells

Purity by SDS-PAGE #: ≥ 97% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 130-140 kDa

Concentration: N/A

Appearance: Sterile Filtered colorless solution

Physical form description: Solid

Reconstitution Instructions: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

Background Information: TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Tie1 and Tie2 are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis, and hematopoiesis. Tie2 may play a role in a range of diseases with a vascular component, including neovascularization of tumors, psoriasis and inflammation. Mutations in the Tie2 gene are associated with dominantly inherited venous malformations (VMCM). Tie2 is required for normal angiogenesis and heart development during embryogenesis, and for post-natal hematopoiesis. Tie2 may activate or inhibit angiogenesis, depending on the context. Tie2 may have anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels.

Amino acid sequence: The target protein is expressed with sequence (Ala23-Lys745) of human Tie2/CD202b/TEK

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans