Human CellExp™ TPBG, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, Wnt-activated inhibitory factor 1, WAIF1,TPBG

Alternates names: Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, Wnt-activated inhibitory factor 1, WAIF1,TPBG

Taglines: Antagonist of the of Wnt/β-catenin signaling pathway

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 7162

NCBI Gene Symbol: TPBG

Gene Source: Human

Accession #: Q13641

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS - PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 36.5 kDa (6xHis tag fused to C-terminus with GS linker)

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

Background Information: Trophoblast glycoprotein, also known as TPBG or 5T4, is a human cell surface protein encoded by a TPBG gene and an antagonist of the of Wnt/β-catenin signaling pathway. TPBG/5T4 is rarely expressed in normal adult tissues, but is present at high levels in placenta and in most common tumors, typically more than 80% of carcinomas of the kidney, breast, colon, prostate, and ovary. Due to its selective expression, it is often used as a prognostic aid in cancer cases. Recently, it has been shown that TPBG inhibits Wnt/β-catenin signaling, a signaling system central to many developmental and pathological processes and therefore serves as a therapeutic target of several anticancer agents currently in clinical development.

Amino acid sequence: Ser 32 – Ser 355

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans