Human CellExp™ VEGF-D, Human recombinant

Biomolecule/Target: VEGFD

Synonyms: FIGF, VEGFD

Alternates names: FIGF, VEGFD

Taglines: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2277

NCBI Gene Symbol: VEGFD

Gene Source: Human

Accession #: O43915

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human VEGF R3, Fc Tag at 5μg/mL (100 μl/well) can bind Human VEGF-D, His Tag, Strep Tag with a linear range of 0.08-0.6 μg/ml.

Results: N/A

Binding Capacity: Immobilized Human VEGF R3, Fc Tag at 5μg/mL (100 μl/well) can bind Human VEGF-D, His Tag, Strep Tag with a linear range of 0.08-0.6 μg/ml.

Unit Definition: N/A

Molecular Weight: 13 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans