Human CellExp™ E-Cadherin /ECAD /Cadherin-1/CD324, (Fc Tag), Human Recombinant

Biomolecule/Target: N/A

Synonyms: Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO

Alternates names: Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO

Taglines: Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 999

NCBI Gene Symbol: CDH1

Gene Source: Human

Accession #: P12830

Recombinant: True

Source: HEK293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.3 kDa. The protein migrates as 100 kDa and 120 kDa Cadherin, a 48 kDa Propeptide under reducing (R) condition (SDS-PAGE) due to different glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile water. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C

Background Information: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).

Amino acid sequence: AA Gln 23 - Pro 621

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans