Human CellExp™ GFR alpha-like, Human Recombinant

Biomolecule/Target: N/A

Synonyms: GFR alpha like, GFR alpha-like, GFRAL, GRAL

Alternates names: GFR alpha like, GFR alpha-like, GFRAL, GRAL

Taglines: Neuronal brainstem receptor mediating the anorectic funtions of GDF15

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 389400

NCBI Gene Symbol: GFRAL

Gene Source: Human

Accession #: Q6UXV0

Recombinant: FALSE

Source: HEK 293 cells

Purity by SDS-PAGE #: >95% as determined by SDS-PAGE.

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.

Background Information: GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

Amino acid sequence: AA Ser 19 - Glu 351

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans