Biovision
Human CellExp™ GFR alpha-like, Human Recombinant
- SKU:
- 26-P1386
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: N/A
Synonyms: GFR alpha like, GFR alpha-like, GFRAL, GRAL
Alternates names: GFR alpha like, GFR alpha-like, GFRAL, GRAL
Taglines: Neuronal brainstem receptor mediating the anorectic funtions of GDF15
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 389400
NCBI Gene Symbol: GFRAL
Gene Source: Human
Accession #: Q6UXV0
Recombinant: FALSE
Source: HEK 293 cells
Purity by SDS-PAGE #: >95% as determined by SDS-PAGE.
Assay: N/A
Purity: N/A
Assay #2: N/A
Endotoxin Level: Less than 1.0 EU per μg by the LAL method
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.
Background Information: GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Amino acid sequence: AA Ser 19 - Glu 351
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans