Human CellExp™LRP-5, Fc tag, Human Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: LRP-5, LRP-5, LRP-7, LRP7, LR3
Alternates names: LRP-5, LRP-5, LRP-7, LRP7, LR3
Taglines: Frizzled protein family members that plays a key role in skeletal homeostasis
Country of Animal Origin: USA
NCBI Gene ID #.: 4041
NCBI Gene Symbol: LRP5
Gene Source: Human
Accession #: O75197-1
Source: HEK 293 cells
Purity by SDS-PAGE #: >90%
Assay #2: N/A
Endotoxin Level: Less than 0.1 EU per μg by the LAL method.
Activity (Specifications/test method): N/A
Biological activity: Immobilized Human Dkk-1, His Tag 5 μg/mL (100 μL/well) can bind Human LRP-5, Mouse IgG2a Fc Tag with a linear range of 0.01-0.313 μg/mL
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 96.6 kDa. The protein migrates as 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Background Information: Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.
Amino acid sequence: Glu 644 - Gln 1263
Handling: Centrifuge the vial prior to opening.