EZSolution™

A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and...

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins...

A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but...

Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC₅₀ = 86 ± 33 µM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and...

Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts...

A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.Alternate...

Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells.Alternate Name/Synonyms:...

Inhibitor of TNF-α processing (IC₅₀ = 100 nM), similar to TAPI-0 (Cat. No. 2067-1), but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α (IC₅₀ = 50-100 μM), APP (1-8 μM), IL6R (5- 10 μM), TNFRI...

A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific cytotoxicity at high concentrations (~100 mM). More...

Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels. However, in clinical trials, Torcetrapib displayed...

Dalcetrapib is a potent CETP modulator. It is a thioester pro-drug that is rapidly hydrolyzed to generate a pharmacologically active thiol. Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise high-density lipoprotein...

Anacetrapib is a potent inhibitor of the cholesteryl ester transfer protein (CETP)-dependent transfer of cholesteryl ester (CE) (IC₅₀ = 17 ± 4.8 nM); it significantly raises HDL cholesterol levels in humans.Alternate Name/Synonyms:...

Supplied as a 100X concentrated sterile-filtered solution. Pencillin/Streptomycin/Amphotericin B contains 10,000 IU/ml of Penicillin potassium (Cat. No. 2504), 10 mg/ml of Streptomycin sulfate (Cat. No. 2501), and 25 μg/ml of Amphotericin B (Cat. No...

Supplied as a 100X concentrated sterile-filtered solution. Pencillin-Streptomycin (Pen/Strep) is an antibacterial solution comprised of Penicillin (10,000 units/ml), a β-lactam, and Streptomycin (10 mg/ml), an aminoglycoside.Alternate Name/Synonyms:...

A solution (34 mg/ml, 0.2 µM sterile filtered) of Chloramphenicol (Cat. No. 2486) in 100% Ethanol. Suitable for cell culture applications.Alternate Name/Synonyms: D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide,...

Ampicillin sodium is a β-lactam antibiotic structurally related to penicillin. Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Ampicillin sodium can be used as a selective agent...

A 10 mM (5 mg in 874 µl) solution of the of the EZH2 inhibitor EPZ6438 (Cat. No.2383) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (1 mg in 178 µl) solution of the of DOT1L methyltransferase inhibitor EPZ5676 (Cat. No. 2382) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (1 mg in 381 µl) solution of the EZH2 inhibitor 3-Deazaneplanocin (Cat. No. 2060) in anhydrous DMSO.Alternate Name/Synonyms: DZNep; NSC 617989;...

A 10 mM (2 mg in 370 µl) solution of the EZH2 inhibitor EPZ-005687 (Cat. No. 2364) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (1 mg in 190 µl) solution of the EZH2 inhibitor GSK126 (Cat. No. 2282) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (1 mg in 185 µl) solution of the EZH2 inhibitor GSK343 (Cat. No. 2281) in anhydrous DMSO.Alternate Name/Synonyms:...

A 100 mM (25 mg in 1007 µl) sterile-filtered solution of Tetrahydrouridine (Cat. No.1671) in H₂O.Alternate Name/Synonyms: 2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-, NSC112907; THUAppearance: LiquidAppearance: A 100 mM solution in...

A potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively) and exhibits 100-fold binding selectivity relative to...

A potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to...

A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent...

Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Ionomycin induces apoptosis in immature B cell lines...

A 10 mM (1 mg in 330 µl) of Trichostatin A (Cat. No. 1606-1) in anhydrous DMSO.Alternate Name/Synonyms: TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamideAppearance: LiquidAppearance: A 10 mM (1 mg in 330 µl) of...

A 10 mM (1 mg in 260 µl) solution of the proteasome inhibitor PS-341 (Cat. No. 1846) in anhydrous DMSO.Alternate Name/Synonyms: MG-341; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acidAppearance: LiquidAppearance:...

A 10 mM (1 mg in 217 µl) solution of the proteasome inhibitor MG-115 (Cat. No. 1831) in anhydrous DMSO.Alternate Name/Synonyms: Z-LL-NVa-CHO; Z-Leu-Leu-Nva-CHO; MG115Appearance: LiquidAppearance: DMSO (10 mM)Appearance: N/AAppearance: YesPeptide...

A 10 mM (1 mg in 219 µl) solution of the Bromodomain inhibitor (+)-JQ1 (Cat. No. 2070-1) in anhydrous DMSO.Alternate Name/Synonyms:...

A 5% solution of the non-ionic detergent Digitonin (Cat.# 2081) in deionized water.Alternate Name/Synonyms: DigitinAppearance: LiquidAppearance: A 5% solution in H₂OAppearance: 11024-24-1Appearance: YesPeptide sequence: N/ASalt Form: N/AMolecular...

A 100 mM (25 mg in 392 μl) solution of BAY 43-9006 (Cat. No.1594-25) in anhydrous DMSO.Alternate Name/Synonyms: Nexavar, SorafenibAppearance: LiquidAppearance: A 100 mM solution in DMSOAppearance: 475207-59-1Appearance: YesPeptide sequence: N/ASalt Form:...

A 10 mM (5 mg in 1.12 ml) solution of Gefitinib (Cat. No. 1589-5) in anhydrous DMSO.Alternate Name/Synonyms: ZD-1839Appearance: LiquidAppearance: A 10 mM solution in DMSOAppearance: 184475-35-2Appearance: YesPeptide sequence: N/ASalt Form: NoMolecular...

A 100 mM (25 mg in 512 µl) solution of Dasatinib (Cat. No. 1586-25) in anhydrous DMSO.Alternate Name/Synonyms: BMS-354825; SprycelAppearance: LiquidAppearance: A 100 mM solution in DMSOAppearance: 302962-49-8Appearance: YesPeptide sequence: N/ASalt Form:...

A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 1645) in anhydrous DMSO.Alternate Name/Synonyms: 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-meth yl-1H-pyrrole-3-propanoic acidAppearance: LiquidAppearance: A 10 mM solution in DMSOAppearance:...

A 10 mM (3.20 mg in 1 ml) solution of the ROCK inhibitor Y-27632, Dihydrochloride (Cat. No. 1596) in deionized water.Alternate Name/Synonyms: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochlorideAppearance: LiquidAppearance: A...

A 5 mM (1.56 mg in 1 ml), sterile-filtered solution of the enhancer of hESCs survival Thiazovivin (Cat. No. 1681) in anhydrous DMSO.Alternate Name/Synonyms: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamideAppearance: LiquidAppearance: A 5 mM...

A 5 mM (1.92 mg in 1 ml), sterile-filtered solution of the ALK5 inhibitor SB-431542 (Cat. No. 1674) in anhydrous DMSO.Alternate Name/Synonyms: 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamideAppearance: LiquidAppearance: A 5 mM...

A 10 mM (4.65 mg in 1 ml), sterile-filtered solution of the GSK-3β inhibitor CHIR99021 (Cat. No. 1677) in anhydrous DMSO.Alternate Name/Synonyms:...

A 5 mM (2.41 mg in 1 ml), sterile-filtered solution of the MEK inhibitor PD-0325901 (Cat. No. 1643) in anhydrous DMSO.Alternate Name/Synonyms: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamideAppearance:...

A 5 mM (2.1 mg in 1 ml), sterile-filtered solution of the ALK5 inhibitor A83-01(Cat. No. 1725) in anhydrous DMSO.Alternate Name/Synonyms: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-p yrazole-1-carbothioamide; A83-01Appearance:...

A 10 mM (1 mg in 260 µl) solution of SB-431542 (Cat. No. 1674-1) in anhydrous DMSO.Alternate Name/Synonyms: 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamideAppearance: LiquidAppearance: 10 mM (DMSO)Appearance: 301836-41-9Appearance:...

A 10 mM (1 mg in 209 µl) solution of PD184352 (Cat. No. 1585-1) in anhydrous DMSO.Alternate Name/Synonyms: CI-1040Appearance: LiquidAppearance: 10 mM (DMSO)Appearance: 212631-79-3Appearance: YesPeptide sequence: N/ASalt Form: NoMolecular Formula:...

A solution (10 mg/ml, 0.2 µM sterile filtered) of Puromycin Dihydrochloride (Cat. No.1860-100) in deionized water. Suitable for cell culture applications.Alternate Name/Synonyms: 3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine...

A 100 mM (25 mg in 469.4 µl) solution of Sunitinib Malate (Cat. No. 1611-25) in anhydrous DMSO.Alternate Name/Synonyms: Sunitinib Maleate, SU-11248, Sutent, PHA-290940AD, PNU-290940ADAppearance: LiquidAppearance: 100 mM (DMSO)Appearance:...

A 100 mM (25 mg in 538.1 µl) solution of Tozasertib (Cat. No. 1595-25) in anhydrous DMSO.Alternate Name/Synonyms: MK-0457, VX6, VX-681Appearance: LiquidAppearance: 100 mM (DMSO)Appearance: 639089-54-6Appearance: YesPeptide sequence: N/ASalt Form:...

A 10 mM (5 mg in 1051 µl) solution of MG-132 (Cat. No.1703-5) in anhydrous DMSO.Alternate Name/Synonyms: Z-Leu-Leu-Leu-CHO; Z-LLL-CHOAppearance: LiquidAppearance: N/AAppearance: 133407-82-6Appearance: YesPeptide sequence: N/ASalt Form: NoMolecular...

A 10 mM (1 mg in 265 µl) solution of SB 203580 (Cat. No. 1712-1) in anhydrous DMSO.Alternate Name/Synonyms: [4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazoleAppearance: LiquidAppearance: 10 mM (DMSO)Appearance:...

A 10 mM (500 µg in 132 µl) solution of Gö 6976 (Cat. No. 1711-500) in anhydrous DMSO.Alternate Name/Synonyms: 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]py- rrolo[3,4-c]carbazole-12-propanenitrile; Go6976; PD 406976Appearance: LiquidAppearance:...

A 10 mM (5 mg in 1550 µl) solution of Y-27632, Dihydrochloride (Cat. No. 1596-5) in deionized water.Alternate Name/Synonyms: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochlorideAppearance: LiquidAppearance: 10 mM...

A 10 mM (5 mg in 1870 µl) solution of PD98059 (Cat. No. 1666-5) in anhydrous DMSO.Alternate Name/Synonyms: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneAppearance: LiquidAppearance: 10 mM (DMSO)Appearance: 167869-21-8Appearance: YesPeptide sequence:...

A 10 mM (5 mg in 1075 µl) solution of CHIR99021 (Cat. No. 1677-5) in anhydrous DMSO.Alternate Name/Synonyms: 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99021Appearance:...

A 10 mM (5 mg/1627 µl) solution of PI -3 Kinase inhibitor LY 294002 (Cat. No.1667-5) in DMSO.Alternate Name/Synonyms: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneAppearance: LiquidAppearance: 10 mM (DMSO)Appearance: 154447-36-6Appearance: YesPeptide...

A 5 mM (5 mg in 1093 µl) solution of Rapamycin (Cat. No. 1568-5) in DMSO.Alternate Name/Synonyms: 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, SirolimusAppearance: LiquidAppearance: 5 mM (DMSO)Appearance: 53123-88-9Appearance:...

A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 1048-01) in DMSO.Alternate Name/Synonyms: Antibiotic AM-2282Appearance: LiquidAppearance: 1 mM (DMSO)Appearance: 62996-74-1Appearance: YesPeptide sequence: N/ASalt Form: NoMolecular Formula:...

A 10 mM ( 1 mg in 221 µl) of Pyrintegrin (Cat. No. 1729-1) in anhydrous DMSO.Alternate Name/Synonyms: N-(Cyclopropylmethyl)-4-(4-(6-hydroxy-3,4-dihydroquinolin-1-(2H)-yl)pyrimidin-2-ylamino)benzenesulfonamideAppearance: LiquidAppearance: 10 mM...

Cell-permeable. A 10 mM (1 mg in 321 µl) solution of Thiazovivin (Cat. No. 1681-1) in anhydrous DMSO.Alternate Name/Synonyms: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamideAppearance: LiquidAppearance: 10 mM (DMSO)Appearance:...

Cell-permeable. A potent and selective γ-secretase inhibitor (IC₅₀ = 17 nM) .Displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC₅₀ values are 48 and...

A 10 mM (1 mg in 125 μl) solution of caspase-3 inhibitor Q-DEVD-OPh (Cat. No. 1175-1) in DMSO.Alternate Name/Synonyms: Q-D(OMe)-E(OMe)-VD(OMe)-OPhAppearance: LiquidAppearance: 10 mM solution in DMSOAppearance: N/AAppearance: YesPeptide sequence: N/ASalt...

A 10 mM (1 mg in 190 µl) solution of the negative control Q-VE-OPh (Cat. No, 1171-1) for the caspase inhibitor Q-VD-OPh (Cat. No. 1170-1) in DMSO.Alternate Name/Synonyms: Q-Val-Glu-OPh; Quinolyl-Val-Glu-OPhAppearance: LiquidAppearance: DMSO (10...

A 10 mM (1 mg in 195 µl) solution of caspase inhibitor Q-VD-OPh (Cat. No, 1170-1) in DMSO.Alternate Name/Synonyms: Q-Val-Asp-OPh; Quinolyl-Val-Asp-OPhAppearance: LiquidAppearance: DMSO (10 mM)Appearance: 1135695-98-5Appearance: YesPeptide sequence:...

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M⁻¹s⁻¹). Also acts as an inhibitor of cathepsin L (k₂= 680,000 M⁻¹s⁻¹).Alternate Name/Synonyms: Z-LLY-FMK, Calpain Inhibitor(fluoromethylketone)Appearance: LiquidAppearance:...