EZSolution™

RNase A is an endoribonuclease that specifically cleaves the single strand RNA at the phosphodiester bond between the 5’-ribose of a nucleotide and the 3’ OH phosphate group of an adjacent pyrimidine nucleotide. The highest activity is demonstrated with...

Biomolecule/Target: N/ASynonyms: Protease K, Endopeptidase K, Tritirachium alkaline proteinaseAlternates names: Protease K, Endopeptidase K, Tritirachium alkaline proteinaseTaglines: A serine protease which inactivates nucleasesTaglines: USACountry of...

Biomolecule/Target: N/ASynonyms: Serratia marcescens binuclease; unrestricted endonucleaseAlternates names: Serratia marcescens binuclease; unrestricted endonucleaseTaglines: For digestion of DNA and RNATaglines: USACountry of Animal Origin: USANCBI Gene...

Propidium iodide (PI) is a nuclear and chromosome counterstain commonly used to detect dead cells in a population. PI binds to double-stranded DNA, but it can only cross the plasma membrane of nonviable cells. When viewed using a fluorescence microscope...

A 10 mM (5 mg in 1.34 ml) of the ATP-competitive c-Met kinase inhibitor (Cat. No. B2062) in anhydrous DMSOAlternate Name/Synonyms: PF04217903, 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanolAppearance:...

A 10 mM (5 mg in 888 µl) of the potent inhibitor of FLT kinase, PDGFRβ and c-Kit Tandutinib (Cat. No. 2024) in anhydrous DMSO.Alternate Name/Synonyms: CT53518,...

A 10 mM (5 mg in 1.13 ml) solution of the FLT3 tyrosine kinase inhibitor Crenolanib (Cat. No. 9679) in anhydrous DMSO.Alternate Name/Synonyms: 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine, ARO 002,...

A 10 mM (5 mg in 1.35 ml) of the CDK inhibitor AZD-5438 (Cat. No. B2073) in anhydrous DMSOAlternate Name/Synonyms: 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amineAppearance: LiquidAppearance: A 10 mM solution in...

A 10 mM (1 mg in 306 µl) of the JAK inhibitor Peficitinib (Cat. No. B2474) in anhydrous DMSOAlternate Name/Synonyms: ASP015K, JNJ-54781532, 4-(((1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide,...

A 10 mM (5 mg in 1.55 ml) of the JAK1 inhibitor PF-04965842 (Cat. No. B2470) in anhydrous DMSOAlternate Name/Synonyms: N-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide, PF04965842, AbrocitinibAppearance:...

A 10 mM (5 mg in 1.28 ml) solution of the potent and selective JAK3 inhibitor Decernotinib (VX-509) in anhydrous DMSO.Alternate Name/Synonyms: (R,Z)-2-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanimidic...

INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. It inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells.Alternate Name/Synonyms: INF 39, Ethyl 2-(2-chlorobenzyl)acrylateAppearance: LiquidAppearance: A 10 mM ( 5 mg in 2.23...

A 10 mM (5 mg in 695 µl) of the potent proteasome inhibitor Carfilzomib (Cat. No. 2385) in anhydrous DMSO.Alternate Name/Synonyms: PR-171; (S)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)...

A 10 mM (5 mg in 1.0 ml) of the potent EGFR inhibitor AZD-9291 (Osimertinib) (Cat. No. 2674) in anhydrous DMSO.Alternate Name/Synonyms: Mereletinib; Osimertinib;...

A 10 mM (5 mg in 941 µl) of the potent MEK inhibitor Cobimetinib (Cat. No. B1689) in anhydrous DMSO.Alternate Name/Synonyms: [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone; XL518; GDC0973;...

A 10 mM (5 mg in 1.38 ml) of the potent proteasome inhibitor Ixazomib (Cat. No. B2384) in anhydrous DMSO.Alternate Name/Synonyms: MLN-2238; MLN2238; (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acidAppearance: LiquidAppearance: A 10...

A 10 mM (1 mg in 212 µl) of the potent JAK2/FLT3 inhibitor Pacritinib (SB1518) (Cat. No. 2450) in anhydrous DMSO.Alternate Name/Synonyms: SB-1518, SB1518, 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)...

A 10 mM (5 mg in 1064 µl) solution of the potent JAK2 inhibitor LY-2784544 (Gandotinib) (Cat. No. B1914) in anhydrous DMSO.Alternate Name/Synonyms: LY-2784544,...

A 10 mM (5 mg in 1.12 ml) solution of the potent Syk and JAK inhibitor Cerdulatinib (Cat. No. 2803) in anhydrous DMSO.Alternate Name/Synonyms: 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide, PRT062070,...

A 10 mM (5 mg in 1.18 ml) solution of the potent JAK1 inhibitor Filgotinib (Cat. No. 2871) in anhydrous DMSO.Alternate Name/Synonyms: N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide, GLPG0634,...

A 10 mM (5 mg in 1.35 ml) of the JAK1 and JAK2 inhibitor Baricitinib (Cat. No. 2842) in anhydrous DMSO.Alternate Name/Synonyms: INCB028050, LY-3009104, LY 3009104,...

A 10 mM (5 mg in 1.48 ml) solution of the JAK inhibitor PF-03394197 (Oclacitinib) in anhydrous DMSO.Alternate Name/Synonyms: Oclacitinib, N-Methyl-1-((1r,4r)-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamideAppearance:...

A 10 mM (5 mg in 1.63 ml) solution of the potent JAK inhibitor Ruxolitinib (Cat. No. 2139) in anhydrous DMSO.Alternate Name/Synonyms: NCB18424; βR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INC18424; INCB...

A 5 mM ( 1 mg in 520 µl) sterile-filtered solution of the broad spectrum MMP inhibitor GM-6001 (Cat. No. 1799) in anhydrous DMSOAlternate Name/Synonyms: Ilomastat,N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan...

A 10 mM (5 mg in 1.67 ml), sterile-filtered solution of the anticancer agent Gemcitabine Hydrochloride (Cat. No. 1759) in deionized waterAlternate Name/Synonyms: Gemcitabine,Gemcitabine, EZSolution™Appearance: LiquidAppearance: A 10 mM sterile-filtered...

A 10 mM (5 mg in 1.47 ml), sterile-filtered solution of the ferroptosis inhibitor Liproxstatin-1 (Cat. No. B2312) in anhydrous DMSOAlternate Name/Synonyms: Liproxstatin-1, EZSolution™,Liproxstatin-1Appearance: LiquidAppearance: A 10 mM sterile-filtered...

A 10 mM (5 mg in 703 μl), sterile-filtered solution of the PDX1 inducer BRD-7552 (Cat. No. B2258) in anhydrous DMSO.Alternate Name/Synonyms: Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4Appearance: LiquidAppearance: N/AAppearance:...

A 10 mM (5 mg in 1163 μl), sterile-filtered solution of the cAMP analog, 8-Br-cAMP (Cat. No. 1837) in anhydrous DMSO.Alternate Name/Synonyms: 8- Bromoadenosine- 3', 5'- cyclic monophosphate; cyclic 8- bromoadenosine- 3', 5'- monophosphate; 8-...

A 10 mM (5 mg in 948 μl), sterile-filtered solution of the p38 MAP kinase inhibitor Doramapimod (Cat. No. 1954) in anhydrous DMSO.Alternate Name/Synonyms: 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea;...

A 5 mM (2 mg in 963 μl), sterile-filtered solution of the BET bromodomain inhibitor I-BET151 (Cat. No. 2220) in anhydrous DMSO.Alternate Name/Synonyms:...

A 5 mM (2 mg in 1.15 ml), sterile-filtered solution of the BET bromodomain inhibitor PFI-1 (Cat. No. 2203) in anhydrous DMSO.Alternate Name/Synonyms: 2-​Methoxy-​N-​(3-​methyl-​2-​oxo-​1,​2,​3,​4-​tetrahydroquinazolin-​6-​yl)benzenesulfonamideAppearance:...

A 10 mM (5 mg in 1.82 ml), sterile-filtered solution of the phosphodiesterase-4 (PDE4) inhibitor Rolipram (Cat. No. 2010) in anhydrous DMSO.Alternate Name/Synonyms: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-oneAppearance: LiquidAppearance:...

A 10 mM (5 mg in 1.53 ml), sterile-filtered solution of the Rho Kinase (ROCK) inhibitor Fasudil (Cat. No.1787) in water.Alternate Name/Synonyms: (1-(5-Isoquinolinesulfonyl)homopiperazine, Monohydrochloride Salt; HA-1077, Monohydrochloride;...

A 10 mM (5 mg in 977 μl), sterile-filtered solution of the gamma- secretase inhibitor BMS-299897 (Cat. No. 9606) in anhydrous DMSO.Alternate Name/Synonyms: (R)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)butanoic...

A 10 mM (5 mg in 1.43 ml), sterile-filtered solution of the RAR agonist TTNPB (Cat. No. 2776) in anhydrous DMSO.Alternate Name/Synonyms: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid; Ro 13-7410Appearance:...

A 10 mM (5 mg in 2.37 ml), sterile-filtered solution of the STAT3 activation inhibitor Stattic (Cat. No. 2625) in anhydrous DMSO.Alternate Name/Synonyms: 6-​Nitro-​1,​1-​dioxide-​benzo[b]thiophene; Stat3 Inhibitor VAppearance: LiquidAppearance:...

A 10 mM (5 mg in 2.13 ml), sterile-filtered solution of the neurogenesis promoter (Cat. No. 2563) in anhydrous DMSO.Alternate Name/Synonyms: N-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamideAppearance: LiquidAppearance: N/AAppearance:...

A 5 mM (2.45 mg in 1 ml), sterile-filtered solution of the Smo agonist SAG (Cat. No. 1939) in anhydrous DMSO.Alternate Name/Synonyms: N-Methyl-N′-(3-pyridinylbenzyl)-N′-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexaneAppearance:...

A 10 mM (5.0 mg in 1.50 ml), sterile-filtered solution of the DNA methyltransferase (DNMT) inhibitor RG-108 (Cat. No. 1679) in anhydrous DMSO.Alternate Name/Synonyms: N-Phthalyl-L-tryptophanAppearance: LiquidAppearance: N/AAppearance:...

A 10 mM (5.0 mg in 1.50 ml), sterile-filtered solution of the HDR (homology-directed repair) enhancer SCR7 Pyrazine (Cat. No. B1119) in anhydrous DMSO.Alternate Name/Synonyms: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinoneAppearance:...

A 10 mM (5.0 mg in 954 μl), sterile-filtered solution of the HDR (homology-directed repair) enhancer RS-1 (Cat. No. B1118) in anhydrous DMSO.Alternate Name/Synonyms: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamideAppearance:...

A 5 mM (5.0 mg in 2.42 ml), sterile-filtered solution of the HDR (homology-directed repair) enhancer NU-7441 (Cat. No. B1117) in anhydrous DMSO.Alternate Name/Synonyms: 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one; KU-57788Appearance:...

A 10 mM (5.0 mg in 1.66 ml), sterile-filtered solution of the HDR (homology-directed repair) enhancer Nocodazole (Cat. No. 2185) in anhydrous DMSO.Alternate Name/Synonyms: 5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl esterAppearance:...

A 10 mM (5.0 mg in 855 μl), sterile-filtered solution of the HDR (homology-directed repair) enhancer L-755,507 (Cat. No. B1116) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (5.0 mg in 1.78 ml), sterile-filtered solution of the HDR (homology-directed repair) enhancer Brefeldin A (Cat. No. 1560) in anhydrous DMSO.Alternate Name/Synonyms: Ascotoxin, BFA, Cyanein, Decumbin,...

A 10 mM (5.06 mg in 1 ml) solution of the neuroprotective agent P7C3-A20 (Cat. No. 2850) in anhydrous DMSO.Alternate Name/Synonyms: N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyanilineAppearance: LiquidAppearance: A 10 mM solution in...

A 10 mM (1 mg in 162 μl) solution of the p53-MDM2 interaction inhibitor RG7388 (Cat. No. 2577) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (10 mg in 3.86 ml) solution of the antitumor and anti-inflammatory agent (R, S)-Lenalidomide (Cat. No. 1862) in anhydrous DMSO.Alternate Name/Synonyms: (R,S)-3-(4-amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dioneAppearance: LiquidAppearance: A 10...

A 10 mM (1 mg in 183 μl) of the antitumor agent Erastin (Cat. No. 2231) in anhydrous DMSO.Alternate Name/Synonyms: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-QuinazolinoneAppearance: LiquidAppearance: A 10 mM...

A 10 mM (10 mg in 2.17 ml), sterile-filtered solution of the necroptosis inhibitor Necrosulfonamide (Cat. No. 9635) in anhydrous DMSO.Alternate Name/Synonyms: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide;...

EZSolution(TM) Triacsicn C, is an Inhibitor of acyl-CoA synthetase (IC₅₀ = 6.3 μM in Raji cells). Inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft...

A 10 mM (5 mg in 1294 µl) of the rapid apoptosis inducer Raptinal (Cat. No. 9626) in anhydrous DMSO.Alternate Name/Synonyms: 9H, 9’H-[9,9’-bifluorene]-9,9’-dicarbaldehydeAppearance: LiquidAppearance: A 10 mM solution in DMSOAppearance: N/AAppearance:...

A 10 mM (5 mg in 1807 µl) of PPARγ antagonist GW9662 (Cat. No. 1697) in anhydrous DMSO.Alternate Name/Synonyms: 2-Chloro-5-nitrobenzanilideAppearance: LiquidAppearance: A 10 mM solution in DMSOAppearance: 22978-25-2Appearance: YesPeptide sequence:...

A 10 mM (5 mg in 1403 µl) of PPARγ agonist Pioglitazone (Cat. No. 1877) in anhydrous DMSO.Alternate Name/Synonyms: 5-​[[4-​[2-​(5-​ethyl-​2-​pyridinyl)ethoxy]phenyl]methyl]-​2,​4-​thiazolidinedioneAppearance: LiquidAppearance: A 10 mM solution in...

A 10 mM (5 mg in 2270 µl) of the JNK inhibitor SP600125 (Cat. No.1669) in anhydrous DMSO.Alternate Name/Synonyms: Anthra[1-9-cd]pyrazol-6(2H)-oneAppearance: LiquidAppearance: 11 mM solution in anhydrous DMSOAppearance: 129-56-6Appearance: YesPeptide...

A 10 mM (1 mg in 226 µl) of PKC inhibitor Gö 6983 (Cat. No.9539) in anhydrous DMSO.Alternate Name/Synonyms: 3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dioneAppearance: LiquidAppearance: 10 mM solution in anhydrous...

A 10 mM (1 mg in 171 µl) of Hsp90 inhibitor 17-AAG (Cat. No.1774) in anhydrous DMSO.Alternate Name/Synonyms: Telatinib; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)geldanamycin; TanespimycinAppearance: LiquidAppearance: A 10 mM solution in...

A 10 mM (1 mg in 264 µl) of potent Wnt signaling pathway inhibitor (Cat. No. 2063) in anhydrous DMSO.Alternate Name/Synonyms: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl)acetamideAppearance: LiquidAppearance: A 10 mM solution in...

A 10 mM (5 mg in 2098 µl) of the VEGFR kinase inhibitor SU-5416 (Cat. No. 9491) in anhydrous DMSO.Alternate Name/Synonyms: 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; SemaxinibAppearance: LiquidAppearance: A 10 mM solution in...

A 10 mM (5 mg in 1456 µl) of the ALK5 inhibitor SB-525334 (Cat. No. 2880) in anhydrous DMSO.Alternate Name/Synonyms: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxalineAppearance: LiquidAppearance: A 10 mM solution in...

A 10 mM (10 mg in 1080 µl) of the EGFR inhibitor Lapatinib ditosylate (Cat. No.1624) in anhydrous DMSO.Alternate Name/Synonyms: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine...

A 10 mM (5 mg in 1038 µl) of the HMG-CoA inhibitor Rosuvastatin (Cat. No. 1955) in anhydrous DMSO.Alternate Name/Synonyms: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic...

5-Fluoroorotic Acid (5-FOA) is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate (OMP) decarboxylase. 5-FOA is toxic to yeast cells that can synthesize the enzyme orotidine-5’-phosphate...

DAF-2 diacetate is a cell-permeable derivative of DAF-2 (Cat. No. 2752) and a very useful indicator of nitric oxide (NO). Upon entry into the cell, DAF-2 diacetate is converted into the less cell-permeable DAF-2 by cellular esterases thus preventing loss...

DAF-2 is a highly sensitive fluorescent indicator commonly used for the detection of nitric oxide (NO). It reacts with NO in the presence of oxygen to yield the highly fluorescent triazolofluorescein (DAF-2T). Fluorescence is monitored using excitation...

A 10 mM (5 mg in 1218 µl) solution of adenylyl cyclase activator Forskolin (Cat. No. 1531) in anhydrous DMSO.Alternate Name/Synonyms: Coleonol, Colforsin, 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-oneAppearance: LiquidAppearance: A 10 mM...

A 10 mM (5 mg in 1019 µl) solution of the HMTase inhibitor BIX01294 (Cat. No. 1678) in anhydrous DMSO.Alternate Name/Synonyms: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamineAppearance:...

A 10 mM (1 mg in 233 µl) of the stem cell fate modulator StemRegenin 1 (Cat. No. 2642) in anhydrous DMSOAlternate Name/Synonyms: 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol; SR1Appearance: LiquidAppearance: N/AAppearance:...

A 10 mM (5 mg in 1740 µl) of the ALK5 inhibitor RepSox (Cat. No. 1894) in anhydrous DMSO.Alternate Name/Synonyms: 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine; E-616452Appearance: LiquidAppearance: N/AAppearance: 446859-33-2Appearance:...

A 10 mM (1 mg in 231 µl) of the ROCK inhibitor GSK429286A (Cat. No. 2637) in anhydrous DMSO.Alternate Name/Synonyms: 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide; GSK429286Appearance:...

A 10 mM (1 mg in 206 µl) of the GSK-3 inhibitor CHIR-98014 (Cat. No. 2595) in anhydrous DMSO.Alternate Name/Synonyms: 6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine; CT 98014Appearance:...

A 10 mM (5 mg in 1744 µl) of the PDK1 activator PS48 (Cat. No. 1869) in anhydrous DMSO.Alternate Name/Synonyms: (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acidAppearance: LiquidAppearance: A 10 mM solution in DMSOAppearance: 1180676-32-7Appearance:...

A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not...

Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1,

Cell-permeable. A potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 µM ATP and no AMP). Does not affect the activity on several structurally related kinases including...

A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and...

A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but...

Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC₅₀ = 86 ± 33 µM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and...

Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts...

A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.Alternate...

A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific cytotoxicity at high concentrations (~100 mM). More...

Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels. However, in clinical trials, Torcetrapib displayed...

Dalcetrapib is a potent CETP modulator. It is a thioester pro-drug that is rapidly hydrolyzed to generate a pharmacologically active thiol. Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise high-density lipoprotein...

Anacetrapib is a potent inhibitor of the cholesteryl ester transfer protein (CETP)-dependent transfer of cholesteryl ester (CE) (IC₅₀ = 17 ± 4.8 nM); it significantly raises HDL cholesterol levels in humans.Alternate Name/Synonyms:...

Supplied as a 100X concentrated sterile-filtered solution. Pencillin/Streptomycin/Amphotericin B contains 10,000 IU/ml of Penicillin potassium (Cat. No. 2504), 10 mg/ml of Streptomycin sulfate (Cat. No. 2501), and 25 μg/ml of Amphotericin B (Cat. No...

Supplied as a 100X concentrated sterile-filtered solution. Pencillin-Streptomycin (Pen/Strep) is an antibacterial solution comprised of Penicillin (10,000 units/ml), a β-lactam, and Streptomycin (10 mg/ml), an aminoglycoside.Alternate Name/Synonyms:...

A solution (34 mg/ml, 0.2 µM sterile filtered) of Chloramphenicol (Cat. No. 2486) in 100% Ethanol. Suitable for cell culture applications.Alternate Name/Synonyms: D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide,...

Ampicillin sodium is a β-lactam antibiotic structurally related to penicillin. Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Ampicillin sodium can be used as a selective agent...

A 10 mM (5 mg in 874 µl) solution of the of the EZH2 inhibitor EPZ6438 (Cat. No.2383) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (1 mg in 178 µl) solution of the of DOT1L methyltransferase inhibitor EPZ5676 (Cat. No. 2382) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (2 mg in 370 µl) solution of the EZH2 inhibitor EPZ-005687 (Cat. No. 2364) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (1 mg in 190 µl) solution of the EZH2 inhibitor GSK126 (Cat. No. 2282) in anhydrous DMSO.Alternate Name/Synonyms:...

A 10 mM (1 mg in 185 µl) solution of the EZH2 inhibitor GSK343 (Cat. No. 2281) in anhydrous DMSO.Alternate Name/Synonyms:...

A potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively) and exhibits 100-fold binding selectivity relative to...

A potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to...

A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent...

A 10 mM (1 mg in 330 µl) of Trichostatin A (Cat. No. 1606-1) in anhydrous DMSO.Alternate Name/Synonyms: TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamideAppearance: LiquidAppearance: A 10 mM (1 mg in 330 µl) of...

A 10 mM (1 mg in 260 µl) solution of the proteasome inhibitor PS-341 (Cat. No. 1846) in anhydrous DMSO.Alternate Name/Synonyms: MG-341; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acidAppearance: LiquidAppearance:...

A 10 mM (1 mg in 217 µl) solution of the proteasome inhibitor MG-115 (Cat. No. 1831) in anhydrous DMSO.Alternate Name/Synonyms: Z-LL-NVa-CHO; Z-Leu-Leu-Nva-CHO; MG115Appearance: LiquidAppearance: DMSO (10 mM)Appearance: N/AAppearance: YesPeptide...

A 10 mM (1 mg in 219 µl) solution of the Bromodomain inhibitor (+)-JQ1 (Cat. No. 2070-1) in anhydrous DMSO.Alternate Name/Synonyms:...